On 27 July 2021, it was announced that Manchester United and Real Madrid had reached an agreement for the transfer of Varane, subject to a medical and the player’s terms being finalised. The transfer was completed on 14 August 2021, after Varane was announced in front of a packed Old Trafford crowd ahead of United’s Premier League opener against Leeds United. He was given the number 19 shirt previously worn by Amad Diallo, which he also wore in his first season with Real Madrid. He made his debut on 29 August 2021 and contributed an assist to the winning goal in a 1–0 win over Wolverhampton Wanderers.
On 2 May 2022, Varane scored his first goal for the club in a 3–0 win over Brentford.
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